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Estimated H-index: 2. B-cell receptors BCRs play a critical role in adaptive immunity as they generate highly diverse immunoglobulin repertoires to recognize a wide variety of antigens.

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To better understand immune responses, it is critically important to establish a quantitative and rapid method to analyze BCR repertoire comprehensively. Using this method and quantitative r Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cells. Published on Jan 13, in Oncotarget.

Taigo Kato 9 Estimated H-index: 9. Estimated H-index: 3. Estimated H-index: 6. Vassiliki Saloura 12 Estimated H-index: Estimated H-index: 1. Estimated H-index: 9.

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Novel treatments are thus urgently awaited. The purpose of this study was to investigate the T-cell receptor repe Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.

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Dung T. Le 30 Estimated H-index: The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed that colorectal cancers with mismatch repair deficiency were sensitive to immune checkpoint blockade with antibodies to programmed death receptor—1 PD We have now expanded this study to evaluate the efficacy of PD-1 blockade in patients with advanced mismatch repair—deficient cancers across 12 different tumor types.

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Objective radiogra Published on Jul 1, in Oncology Letters 1. Redwood , Jonathan G. Peter, Rannakoe Lehloenya, Simon A. Mallal, Elizabeth J.

The Current and Future Applications of Immunopharmacogenomics

Adverse drug reactions ADRs are a significant health care burden. Immune-mediated adverse drug reactions IM-ADRs are responsible for one-fifth of ADRs but contribute a disproportionately high amount of that burden due to their severity. Variation in human leukocyte antigen HLA genes has emerged as a potential preprescription screening strategy for the prevention of previously unpredictable IM-ADRs. Immunopharmacogenomics combines the disciplines of immunogenomics and pharmacogenomics and focuses on the effects of immune-specific variation on drug disposition and IM-ADRs.

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Applications of immunopharmacogenomics : Predicting, preventing, and understanding immune-mediated adverse drug reactions. N2 - Adverse drug reactions ADRs are a significant health care burden. Applications of immunopharmacogenomics: Predicting, preventing, and understanding immune-mediated adverse drug reactions Jason H. Abstract Adverse drug reactions ADRs are a significant health care burden. Pharmaceutical Preparations. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity.

The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies.

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  6. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge. Powered by Koha. Log in to your account.